Psychoactive Amanitas are mushrooms which contain the psychoactive chemicals ibotenic acid and muscimol. They have a long history of use in Asia and Northern Europe. They are best known for their distinctive appearance (bright reds and yellows with white spots).

Cannabis, a fast-growing bushy annual with dense sticky flowers, produces psychoactive cannabinoid chemicals such as THC and CBD. It is the most widely used (still mostly) illegal psychoactive and has a long history of medicinal, recreational, and industrial use. The fibrous stalks of the plant are used to produce clothing and rope. It's legal status is rapidly changing in the US and around the world from top contraband to tolerated mind-alterant along side alcohol and caffeine.

Most psychoactive cacti contain mescaline as their primary active chemical. The best known of these are San Pedro, Peruvian Torch, and Peyote.

Ayahuasca is a powerfully entheogen from South American. One of its primary effects is considered to be the vomiting (the purge) that accompanies the experience. The term ayahuasca is used for spiritual growth.

 iboga’s roots lie in traditional African spiritual ceremonies, it and it’s related alkaloids hold much promise as a potential treatment for addiction and possibly depression, especially when combined with social support and a structured treatment plan 

Psilocybin can significantly and sustainably reduce symptoms of severe depression in people who suffer from depressive disorders. In addition, Psilocybin has also been shown to reduce thoughts of suicide and self-harm.